Genetic Variations in DNA Methyltransferases and Their Link to Breast Cancer: Findings from a Nested Case-Control Analysis in the Arkansas Rural Community Health Study - Takeaways - MDSpire

Genetic Variations in DNA Methyltransferases and Their Link to Breast Cancer: Findings from a Nested Case-Control Analysis in the Arkansas Rural Community Health Study

  • By

  • Sarah A. Mayberry

  • Ping-Ching Hsu

  • Hui-Yi Lin

  • Lora J. Rogers

  • Shelbie D. Stahr

  • L. Joseph Su

  • February 10, 2026

  • 0 min

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  • 1

    Breast cancer is the most diagnosed cancer among women in the U.S., with about one in eight women diagnosed during their lifetime.

  • 2

    DNA methylation, regulated by DNA methyltransferases (DNMTs), plays a critical role in gene expression and cancer development.

  • 3

    The study analyzed genetic polymorphisms in DNMT genes to assess their association with breast cancer risk in a rural Arkansas population.

  • 4

    A nested case-control study included 1484 breast cancer cases and 2154 controls from the Arkansas Rural Community Health study.

  • 5

    The research aims to enhance understanding of how SNPs in DNMTs influence breast cancer susceptibility and treatment outcomes.

Original Source(s)

Genetic Variations in DNA Methyltransferases and Their Link to Breast Cancer: Findings from a Nested Case-Control Analysis in the Arkansas Rural Community Health Study

  • by Sarah A. Mayberry, Ping-Ching Hsu, Hui-Yi Lin, Lora J. Rogers, Shelbie D. Stahr, L. Joseph Su

  • February 10, 2026

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