Metabolomic and inflammatory signatures in congenital hypothyroidism: a longitudinal analysis of levothyroxine response - Takeaways - MDSpire

Metabolomic and inflammatory signatures in congenital hypothyroidism: a longitudinal analysis of levothyroxine response

  • By

  • Marcela Vela-Amieva

  • Isabel Ibarra-González

  • Raúl Calzada León

  • María de la Luz Ruiz-Reyes

  • María Eugenia Constantini

  • Sara Guillén-López

  • Lizbeth López-Mejía

  • Michelle Citlalli Luna-Nequiz

  • Rosa Itzel Carrillo-Nieto

  • Cynthia Fernández-Lainez

  • July 1, 2026

  • 0 min

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  • 1

    The study involved 11 pediatric patients with congenital hypothyroidism undergoing levothyroxine treatment.

  • 2

    Metabolomic profiling revealed nine metabolites that differentiated pre-treatment and post-treatment samples.

  • 3

    Sphingolipid metabolism showed significant changes, with reduced ceramides and increased sphingomyelins after treatment.

  • 4

    Inflammatory markers TNF-α and IL-10 were elevated at diagnosis and showed a decreasing trend post-treatment.

  • 5

    Nutritional assessment indicated a modest increase in length-for-age Z-score in patients after achieving biochemical euthyroidism.

Original Source(s)

Metabolomic and inflammatory signatures in congenital hypothyroidism: a longitudinal analysis of levothyroxine response

  • by Marcela Vela-Amieva, Isabel Ibarra-González, Raúl Calzada León, María de la Luz Ruiz-Reyes, María Eugenia Constantini, Sara Guillén-López, Lizbeth López-Mejía, Michelle Citlalli Luna-Nequiz, Rosa Itzel Carrillo-Nieto, Cynthia Fernández-Lainez

  • July 1, 2026

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