Dysregulation of Stress Erythropoiesis and Enhanced Susceptibility to Salmonella Typhimurium Infection in Aryl Hydrocarbon Receptor–Deficient Mice - Takeaways - MDSpire

Dysregulation of Stress Erythropoiesis and Enhanced Susceptibility to Salmonella Typhimurium Infection in Aryl Hydrocarbon Receptor–Deficient Mice

  • By

  • Michelle Mayer

  • Sevgi C Cengiz-Dartenne

  • Manja Thiem

  • Philip Hatzfeld

  • Adrian Semeniuk

  • Nancy Wang

  • Richard A Strugnell

  • Irmgard Förster

  • Heike Weighardt

  • June 6, 2024

  • 0 min

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  • 1

    AhR-deficient mice exhibit increased susceptibility to Salmonella Typhimurium infection, resulting in higher bacterial loads and mortality compared to wild type mice.

  • 2

    Infection with Salmonella Typhimurium in AhR-deficient mice leads to macrocytic anemia and significant splenomegaly with destruction of splenic architecture.

  • 3

    AhR deficiency is associated with enhanced stress erythropoiesis, indicated by increased splenic immature red blood cells and elevated serum erythropoietin and interleukin 6.

  • 4

    The exacerbated stress erythropoiesis in AhR-deficient mice likely disrupts splenic immune cell compartments, impairing effective host defense against Salmonella.

  • 5

    Chronic Salmonella infection in AhR-deficient mice mimics human typhoid fever, highlighting the critical role of AhR in regulating immune responses to pathogens.

Original Source(s)

Dysregulation of Stress Erythropoiesis and Enhanced Susceptibility to Salmonella Typhimurium Infection in Aryl Hydrocarbon Receptor–Deficient Mice

  • by Michelle Mayer, Sevgi C Cengiz-Dartenne, Manja Thiem, Philip Hatzfeld, Adrian Semeniuk, Nancy Wang, Richard A Strugnell, Irmgard Förster, Heike Weighardt

  • June 6, 2024

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