Integrating multiomics to elucidate the role of chromatin remodeling in glioma and the antitumor mechanisms and therapeutic potential of targeting LMNA

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Glioma is a highly aggressive CNS malignancy with poor clinical outcomes, necessitating the identification of prognostic tools and therapeutic targets.
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The study identified chromatin remodeling-related genes (CRRGs) that are differentially expressed in glioma compared to normal brain tissues.
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Consensus clustering revealed two CRRG-based glioma subtypes, with one subgroup showing significantly better prognoses.
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LMNA was identified as a core gene correlated with poor survival, and its depletion impaired tumor cell proliferation and invasion.
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The developed CRRG-based prognostic signature demonstrates clinical utility, highlighting LMNA as a promising therapeutic target in glioma.

Frontiers In Immunology

by Kun Wang, Feini Xu, Lingjie Zhu, Jiaying Wang, Haibo Li, Xianwen Cao, Xuhan Wang, Da Zong, Yuankun Liu, Junfei Shao
May 8, 2026

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