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1
Dysbiosis in the neonatal microbiome is linked to severe infections, including late-onset meningitis, which has high mortality and poor outcomes.
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2
Preterm infants are particularly vulnerable to microbiome disruptions due to factors like cesarean delivery and antibiotic exposure.
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3
Late-onset meningitis can be preceded by intestinal pathogen outgrowth, detectable before clinical symptoms appear.
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4
The study identified significant microbiota changes in neonates with late-onset meningitis, including increased Pseudomonadota and decreased Bacillota.
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5
Early intervention strategies, such as probiotics, may help protect preterm infants from serious infections linked to microbiome dysregulation.
