Maternal, healthcare, and nutritional factors influencing birth defects in China from 2019 to 2025: a systematic review and meta-analysis - Takeaways - MDSpire

Maternal, healthcare, and nutritional factors influencing birth defects in China from 2019 to 2025: a systematic review and meta-analysis

  • By

  • Min Yang

  • Jia Lv

  • Tianzhi Guo

  • Min Ren

  • Lingling Xie

  • Suhua Tu

  • July 3, 2026

  • 0 min

Share

  • 1

    This systematic review evaluates factors influencing birth defects in China from 2019 to 2025, analyzing 25 studies with 26,019 cases.

  • 2

    Seventeen influencing factors were identified, including maternal age, BMI, drug use, and healthcare service access.

  • 3

    Irregular folic acid supplementation was linked to increased risk of neural tube defects, with an odds ratio of 2.34.

  • 4

    Subgroup analyses revealed reduced heterogeneity for factors like adverse pregnancy history and preterm birth.

  • 5

    The study highlights the need for targeted interventions on controllable factors to reduce birth defect incidence in China.

Original Source(s)

Maternal, healthcare, and nutritional factors influencing birth defects in China from 2019 to 2025: a systematic review and meta-analysis

  • by Min Yang, Jia Lv, Tianzhi Guo, Min Ren, Lingling Xie, Suhua Tu

  • July 3, 2026

Related Content

Acupuncture for premature ovarian insufficiency: a systemic neuroendocrine perspective

Development and validation of a blood biomarker risk prediction model for postmenopausal endometrioid endometrial cancer

Effects of Balint group combined with mindfulness-based stress reduction on humanistic care ability and psychological resilience among obstetric nurses