Association of semen leukocytes with sperm DNA fragmentation in a clinical cohort - Takeaways - MDSpire

Association of semen leukocytes with sperm DNA fragmentation in a clinical cohort

  • By

  • Lijun Peng

  • Tengfei Wang

  • Mengyi Zhu

  • Yun Le

  • Sheng Yang

  • May 21, 2026

  • 0 min

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  • 1

    Sperm DNA fragmentation index (DFI) correlates with male reproductive health and is influenced by age and semen parameters.

  • 2

    Semen leukocytes positively correlate with DFI, indicating a nonlinear relationship affecting sperm DNA integrity.

  • 3

    Conventional semen parameters and CASA kinematics show an inverse correlation with DFI, impacting sperm motility.

  • 4

    Albumin exhibits a strong inverse relationship with DFI, suggesting its role as a systemic biomarker for sperm DNA fragmentation.

  • 5

    The study developed a predictive model for high DFI risk, demonstrating good internal validation but requiring external validation for clinical use.

Original Source(s)

Association of semen leukocytes with sperm DNA fragmentation in a clinical cohort

  • by Lijun Peng, Tengfei Wang, Mengyi Zhu, Yun Le, Sheng Yang

  • May 21, 2026

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