Lactylation-mediated remodelling of the breast cancer microenvironment: single-cell multidimensional analysis and prognostic model construction - Takeaways - MDSpire

Lactylation-mediated remodelling of the breast cancer microenvironment: single-cell multidimensional analysis and prognostic model construction

  • By

  • Jiaxin Chen

  • Yixue Hao

  • Yinghua Feng

  • Yongjing Dai

  • Haoyuan Shi

  • Li Zhu

  • May 13, 2026

  • 0 min

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  • 1

    Lactylation, a post-translational modification from lactate, links metabolic reprogramming to immune and transcriptional changes in breast cancer.

  • 2

    Single-cell analysis of 98,572 cells revealed significant heterogeneity in breast cancer subtypes, particularly in epithelial cells.

  • 3

    A 14-gene prognostic model was developed and validated, effectively classifying patients into distinct risk categories across multiple datasets.

  • 4

    High lactylation scores in epithelial cells correlated with immune-modulatory microenvironments and unique immune/stromal profiles.

  • 5

    CALR knockdown experiments demonstrated lactylation's role in inhibiting cell proliferation and promoting apoptosis in breast cancer cells.

Original Source(s)

Lactylation-mediated remodelling of the breast cancer microenvironment: single-cell multidimensional analysis and prognostic model construction

  • by Jiaxin Chen, Yixue Hao, Yinghua Feng, Yongjing Dai, Haoyuan Shi, Li Zhu

  • May 13, 2026

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