Immune remodeling and metabolic reprogramming in chronic fatigue: insights into GPCR signaling and epigenetic regulation - Takeaways - MDSpire

Immune remodeling and metabolic reprogramming in chronic fatigue: insights into GPCR signaling and epigenetic regulation

  • By

  • Zekai Hu

  • Jinyan Wang

  • Sicong Ma

  • Jie Zhuang

  • Jing Shi

  • Yan Zhu

  • May 15, 2026

  • 0 min

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  • 1

    Chronic fatigue is a significant symptom in various inflammatory conditions, impacting patients' quality of life and complicating disease prognosis.

  • 2

    Metabolic dysregulation, including mitochondrial dysfunction and altered glycolysis, plays a crucial role in the inflammation-fatigue axis.

  • 3

    G protein-coupled receptor (GPCR) signaling is highlighted as a key regulatory interface in inflammatory and metabolic pathways related to fatigue.

  • 4

    Epigenetic modifications, such as histone acylation, may influence immune cell function and contribute to fatigue-related biology.

  • 5

    The review provides a framework for understanding fatigue across inflammatory disorders, emphasizing shared mechanisms and potential therapeutic targets.

Original Source(s)

Immune remodeling and metabolic reprogramming in chronic fatigue: insights into GPCR signaling and epigenetic regulation

  • by Zekai Hu, Jinyan Wang, Sicong Ma, Jie Zhuang, Jing Shi, Yan Zhu

  • May 15, 2026

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