Single-fraction Gamma Knife radiosurgery for pineal region meningiomas: a retrospective single-center cohort of 44 patients

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Gamma Knife Radiosurgery (GKRS) is a minimally invasive treatment option for pineal region meningiomas, which are rare intracranial tumors.
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This study analyzed 44 patients treated with single-fraction GKRS, representing one of the largest cohorts for this tumor location.
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Local tumor control, overall survival, and progression-free survival were evaluated, with specific dosimetric constraints applied during GKRS.
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Adverse radiation effects were assessed, with new peritumoral edema classified as asymptomatic or symptomatic based on MRI findings.
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The study aimed to provide long-term data on tumor control and safety outcomes for patients with meningiomas in the pineal region.

Journal Of Neuro-Oncology (Springer)

by Ali Haluk Duzkalir, Dogu Cihan Yildirim, Mehmet Orbay Askeroglu, Selcuk Peker
April 14, 2026

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