Serum ferritin critical threshold fluctuations predict antipsychotic treatment discontinuation in pediatric Tic disorders: a retrospective cohort study - Takeaways - MDSpire

Serum ferritin critical threshold fluctuations predict antipsychotic treatment discontinuation in pediatric Tic disorders: a retrospective cohort study

  • By

  • Linxia Li

  • Xianjin Yao

  • Jianing Dou

  • Xiaoping Qian

  • Zhanli Liu

  • Shasha Liu

  • Zelin Hao

  • June 19, 2026

  • 0 min

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  • 1

    Dynamic fluctuations in serum ferritin below 30 ng/mL predict antipsychotic treatment discontinuation in children with tic disorders.

  • 2

    High-fluctuation patients had a discontinuation rate of 60.3%, significantly higher than the 24.0% rate in low-fluctuation patients.

  • 3

    After adjustment, high ferritin fluctuation was associated with over a 2-fold increased risk of treatment discontinuation.

  • 4

    The association between ferritin fluctuation and discontinuation was stronger for typical antipsychotics compared to atypical agents.

  • 5

    Baseline ferritin levels below 30 ng/mL alone did not predict treatment discontinuation, indicating the importance of fluctuation.

Original Source(s)

Serum ferritin critical threshold fluctuations predict antipsychotic treatment discontinuation in pediatric Tic disorders: a retrospective cohort study

  • by Linxia Li, Xianjin Yao, Jianing Dou, Xiaoping Qian, Zhanli Liu, Shasha Liu, Zelin Hao

  • June 19, 2026

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