The impact of disopyramide on exercise capacity among patients with obstructive hypertrophic cardiomyopathy: beyond left ventricular outflow tract gradient - Takeaways - MDSpire

The impact of disopyramide on exercise capacity among patients with obstructive hypertrophic cardiomyopathy: beyond left ventricular outflow tract gradient

  • By

  • Geza Halasz

  • Lorenzo Lupo Dei

  • Francesco Moroni

  • Michael P Ayers

  • Paolo Ciacci

  • Guido Giacalone

  • Raffaella Mistrulli

  • Marco Redivo

  • Santiago Orellana

  • Domenico Gabrielli

  • Massimo Piepoli

  • Federica Re

  • June 8, 2024

  • 0 min

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  • 1

    Hypertrophic cardiomyopathy (HCM) often leads to obstructive HCM (oHCM), causing significant symptoms like syncope and exercise intolerance.

  • 2

    Disopyramide, traditionally used after first-line treatments, shows promise in reducing left ventricular outflow tract obstruction (LVOTO) in oHCM patients.

  • 3

    After 3 months of disopyramide treatment, patients exhibited a significant decrease in peak exercise gradient and resting heart rate.

  • 4

    Despite improvements in LVOTO and symptoms, disopyramide treatment resulted in a significant reduction in peak oxygen consumption (pVO2).

  • 5

    This study indicates that while disopyramide improves symptoms and LVOTO, it does not enhance exercise capacity or pVO2 in oHCM patients.

Original Source(s)

The impact of disopyramide on exercise capacity among patients with obstructive hypertrophic cardiomyopathy: beyond left ventricular outflow tract gradient

  • by Geza Halasz, Lorenzo Lupo Dei, Francesco Moroni, Michael P Ayers, Paolo Ciacci, Guido Giacalone, Raffaella Mistrulli, Marco Redivo, Santiago Orellana, Domenico Gabrielli, Massimo Piepoli, Federica Re

  • June 8, 2024

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