Estimate selection determines the apparent mortality threshold at 13 mL/kg/h - Takeaways - MDSpire
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Selection of Estimation Influences the Observed Mortality Threshold at 13 mL/kg/h

  • By

  • Shuhao Mei

  • Hailian Yi

  • Yuyin Han

  • Boran Dong

  • Yong Liu

  • Xiaoyang Gong

  • September 15, 2026

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  • 1

    Lumlertgul et al. reported an association between very-low-dose CRRT (<13 mL/kg/h) and increased 90-day mortality with an odds ratio of 1.72.

  • 2

    The apparent mortality threshold for CRRT varies based on the estimation method used, particularly between conventional and marginal structural Cox models.

  • 3

    Faria and Libório's analysis indicated that adjusting for time-dependent factors nullified the baseline association with the 13 mL/kg/h threshold.

  • 4

    The review protocol lacked guidance on selecting among multiple adjusted estimates, leading to potential bias in reported results.

  • 5

    The authors recommend clarifying the estimate selection process and addressing inconsistencies in reporting to enhance methodological credibility.

Original Source(s)

Estimate selection determines the apparent mortality threshold at 13 mL/kg/h

  • by Shuhao Mei, Hailian Yi, Yuyin Han, Boran Dong, Yong Liu, Xiaoyang Gong

  • September 15, 2026

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