SCO‑792 alleviates HFD‑aggravated chronic pancreatitis by modulating the gut–pancreas axis via the AMPK/ACC and TLR4/NF‑κB signaling pathways - Takeaways - MDSpire
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SCO-792 Reduces High-Fat Diet-Induced Chronic Pancreatitis by Influencing the Gut-Pancreas Interaction Through AMPK/ACC and TLR4/NF-κB Pathways

  • By

  • Yanru Kang

  • Ningning Sun

  • Weijie Yao

  • Jinyu Li

  • Hua Yin

  • Jiyue Wang

  • Zuozheng Wang

  • Shaoqi Yang

  • Xiaoli Yang

  • September 3, 2026

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  • 1

    SCO-792 is a novel enteropeptidase inhibitor that mitigates high-fat diet-induced chronic pancreatitis in mouse models.

  • 2

    The study demonstrated that SCO-792 reduces pancreatic injury and fibrosis by regulating the AMPK/ACC and TLR4/NF-κB pathways.

  • 3

    SCO-792 reconstitutes gut microbiota composition, increasing beneficial bacteria like Akkermansia and promoting short-chain fatty acid production.

  • 4

    Preservation of intestinal barrier integrity by SCO-792 limits serum lipopolysaccharide translocation, reducing systemic inflammation.

  • 5

    Supplementation with Akkermansia or propionate also protects against high-fat diet-induced chronic pancreatitis through similar mechanisms.

Original Source(s)

SCO‑792 alleviates HFD‑aggravated chronic pancreatitis by modulating the gut–pancreas axis via the AMPK/ACC and TLR4/NF‑κB signaling pathways

  • by Yanru Kang, Ningning Sun, Weijie Yao, Jinyu Li, Hua Yin, Jiyue Wang, Zuozheng Wang, Shaoqi Yang, Xiaoli Yang

  • September 3, 2026

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