Cause of chronic diarrhoea By Tingting Cao Honggang Wang May 1, 2026 0 min Gut Share Summary Takeaways Listen Insight Report Clinical Scorecard Quiz Poll 1 A 52-year-old man presented with chronic diarrhea and significant weight loss, leading to a BMI of 14.9 kg/m². 2 Laboratory tests indicated anemia, low serum protein, and elevated IgM and β2-microglobulin levels. 3 Histological examination revealed marked villous blunting and dilated lymphatic vessels in the terminal ileum. 4 The diagnosis was Waldenström’s macroglobulinaemia with intestinal lymphangiectasia, confirmed by immunophenotyping and genetic testing. 5 Treatment with the RCD regimen resulted in improved symptoms and nutritional status, with significant regression of intestinal lesions.
