Cause of chronic diarrhoea - Takeaways - MDSpire

Identifying the Underlying Factors of Chronic Diarrhea

By
Tingting Cao
Honggang Wang
May 1, 2026

Gut

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1

A 52-year-old man presented with chronic diarrhea and significant weight loss, leading to a BMI of 14.9 kg/m².
2

Laboratory tests indicated anemia, low serum protein, and elevated IgM and β2-microglobulin levels.
3

Histological examination revealed marked villous blunting and dilated lymphatic vessels in the terminal ileum.
4

The diagnosis was Waldenström’s macroglobulinaemia with intestinal lymphangiectasia, confirmed by immunophenotyping and genetic testing.
5

Treatment with the RCD regimen resulted in improved symptoms and nutritional status, with significant regression of intestinal lesions.

Original Source(s)

Gut

Cause of chronic diarrhoea

by Tingting Cao, Honggang Wang
May 1, 2026

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