When one size doesn’t fit all: aciclovir dosing and the obesity challenge - Takeaways - MDSpire

When one size doesn’t fit all: aciclovir dosing and the obesity challenge

  • By

  • Maria Solovyeva

  • Calandra Feather

  • Nicholas Appelbaum

  • Elliott Gordon

  • June 17, 2026

  • 0 min

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  • 1

    Conventional weight-based and BSA-based dosing for aciclovir may lead to underdosing or toxicity in obese pediatric patients.

  • 2

    Pharmacovigilance data indicate over 100 pediatric adverse reactions to aciclovir since 2015, highlighting treatment-related harm.

  • 3

    The British National Formulary for Children recommends different dosing strategies based on age, but abrupt transitions can lead to significant dose drops.

  • 4

    Using adjusted body weight in BSA calculations may improve dosing accuracy for children above the 50th weight centile.

  • 5

    A blended dosing approach could provide smoother transitions between dosing regimens, addressing the challenges posed by obesity.

Original Source(s)

When one size doesn’t fit all: aciclovir dosing and the obesity challenge

  • by Maria Solovyeva, Calandra Feather, Nicholas Appelbaum, Elliott Gordon

  • June 17, 2026

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