The cardiovascular risk marker itaconate is sex-dependently associated with legume intake and immune-inflammatory competence in subjects with high BMI - Takeaways - MDSpire

The cardiovascular risk marker itaconate is sex-dependently associated with legume intake and immune-inflammatory competence in subjects with high BMI

  • By

  • Amanda Cuevas-Sierra

  • Andrea Higuera-Gómez

  • Begoña de Cuevillas

  • Gabriela Paula-Buestan

  • María Martínez-Urbistondo

  • Raquel Castejón

  • J. Antonio Vargas

  • José Moisés Laparra

  • J. Alfredo Martínez

  • June 2, 2026

  • 0 min

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  • 1

    Itaconate is produced by activated macrophages and is linked to inflammatory responses and cardiovascular risk.

  • 2

    The study analyzed the relationship between circulating itaconate, dietary legume consumption, and immune-inflammatory markers in individuals with elevated BMI.

  • 3

    Higher legume consumption correlated with a healthier lifestyle but did not affect circulating itaconate levels.

  • 4

    Monocyte counts were independently associated with circulating itaconate, showing an inverse relationship with IL-6 levels.

  • 5

    Significant sex-specific differences were found, with an inverse association between itaconate and monocyte counts in men but not in women.

Original Source(s)

The cardiovascular risk marker itaconate is sex-dependently associated with legume intake and immune-inflammatory competence in subjects with high BMI

  • by Amanda Cuevas-Sierra, Andrea Higuera-Gómez, Begoña de Cuevillas, Gabriela Paula-Buestan, María Martínez-Urbistondo, Raquel Castejón, J. Antonio Vargas, José Moisés Laparra, J. Alfredo Martínez

  • June 2, 2026

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