Risk factors for prolonged respiratory support in late preterm infants: a LASSO-Cox regression analysis - Takeaways - MDSpire

Risk factors for prolonged respiratory support in late preterm infants: a LASSO-Cox regression analysis

  • By

  • Yu Huang

  • Xiao-Shuang Bao

  • Na Sun

  • Kai Li

  • Cheng-Cheng Huang

  • Shi-Fai Zhang

  • June 10, 2026

  • 0 min

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  • 1

    The study analyzed 365 late preterm infants to identify factors influencing the duration of respiratory support using LASSO-Cox regression.

  • 2

    Risk factors for prolonged respiratory support included multiple pregnancy, elevated superoxide dismutase, and albumin-to-globulin ratio.

  • 3

    Protective factors identified were nasal continuous positive airway pressure, lymphocyte percentage, and lactate dehydrogenase.

  • 4

    The LASSO-Cox nomogram achieved a C-index of 0.677, indicating moderate-to-good discrimination for predicting weaning.

  • 5

    SHAP analysis highlighted superoxide dismutase, nasal continuous positive airway pressure, and lymphocyte percentage as key contributors to the model.

Original Source(s)

Risk factors for prolonged respiratory support in late preterm infants: a LASSO-Cox regression analysis

  • by Yu Huang, Xiao-Shuang Bao, Na Sun, Kai Li, Cheng-Cheng Huang, Shi-Fai Zhang

  • June 10, 2026

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