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1
Leukemia treatments, including chemotherapy and stem cell transplantation, are highly gonadotoxic, leading to infertility and endocrine dysfunction in female survivors.
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2
Ovarian tissue cryopreservation is the primary fertility preservation option for prepubertal girls, but it carries risks of leukemic cell contamination.
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3
Leukemic cell infiltration into ovarian tissue raises concerns about the integrity and function of the ovarian reserve, potentially affecting fertility.
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4
Standard cancer treatments can cause irreversible depletion of the ovarian reserve, resulting in primary ovarian insufficiency and long-term infertility.
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5
This review highlights the need for improved strategies to safely preserve fertility in female leukemia patients, considering both leukemic risks and treatment impacts.
