Complement activation in patients with post-acute sequelae after SARS-CoV-2 infection - Takeaways - MDSpire

Complement activation in patients with post-acute sequelae after SARS-CoV-2 infection

  • By

  • Madlene Holmqvist

  • Dick J. Sjöström

  • Katherine Carlson

  • Birgitta Gullstrand

  • Anders A. Bengtsson

  • Robin Kahn

  • Tom E. Mollnes

  • Per Åkesson

  • Per H. Nilsson

  • Fredrik Kahn

  • May 13, 2026

  • 0 min

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  • 1

    Post-acute sequelae of SARS-CoV-2 (PASC) affects approximately 65 million people globally, with symptoms persisting for at least two months post-infection.

  • 2

    The study assessed complement activation indicators in 38 individuals with mild PASC and 10 with severe PASC, compared to 80 fully recovered controls.

  • 3

    No significant differences in complement activation markers were found between PASC patients and the control group.

  • 4

    The research suggests that complement system activation may not play a crucial role in the pathophysiology of PASC.

  • 5

    The study received ethical approval and adhered to standards for human experimentation as outlined in the Helsinki Declaration.

Original Source(s)

Complement activation in patients with post-acute sequelae after SARS-CoV-2 infection

  • by Madlene Holmqvist, Dick J. Sjöström, Katherine Carlson, Birgitta Gullstrand, Anders A. Bengtsson, Robin Kahn, Tom E. Mollnes, Per Åkesson, Per H. Nilsson, Fredrik Kahn

  • May 13, 2026

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