Diffusion levels for quantitative assessment of the apparent diffusion coefficient value in prostate MRI: a proof-of-concept bicentric study

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Diffusion-weighted imaging (DWI) is essential for assessing prostate lesions and influences biopsy decisions based on PI-RADS categories.
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The apparent diffusion coefficient (ADC) is a potential biomarker for prostate cancer but lacks standardized quantification methods due to measurement variability.
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ADC ratios have shown promise in differentiating malignancy but face challenges in reproducibility and added value in clinical practice.
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The study aims to establish diffusion levels (DLs) from prostate MRI data to standardize ADC interpretation and improve diagnostic accuracy.
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A bicentric dataset was used to evaluate the diagnostic performance of DLs in assessing clinically significant prostate cancer.

European Radiology

by Rossano Girometti, Valeria Peruzzi, Paola Clauser, Nina Pötsch, Maria De Martino, Miriam Isola, Gianluca Giannarini, Alessandro Crestani, Chiara Zuiani, Lorenzo Cereser, Pascal AT Baltzer
April 7, 2025

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