Plasma biomarker profiles in ageing: decoding neurodegeneration in vivo

1

Plasma biomarkers are effective tools for mapping neurodegenerative diseases, particularly Alzheimer's disease, rivaling traditional diagnostic methods.
2

A study analyzed 405 older adults, revealing mixed neuropathologies in nearly 80% of participants, highlighting the complexity of aging brains.
3

Three distinct plasma biomarker profiles were identified, correlating with varying degrees of cognitive impairment and neuropathological features.
4

Profile 2, associated with mild cognitive impairment and dementia, showed elevated p-tau217 and GFAP levels, indicating amyloid and tau pathology.
5

The study emphasizes the need for further research to develop plasma biomarkers for TDP-43 and α-synuclein pathologies, which remain unaddressed.

1