Concurrent B-cell acute lymphoblastic leukemia and plasma cell neoplasm with plasmablastic features supporting divergent evolution from a shared precursor: a case report - Takeaways - MDSpire

Concurrent B-cell acute lymphoblastic leukemia and plasma cell neoplasm with plasmablastic features supporting divergent evolution from a shared precursor: a case report

  • By

  • Antonija Babić

  • Ivana Franić Šimić

  • Josip Knežević

  • Koraljka Gjadrov Kuveždić

  • Ivana Ilić

  • Ida Ivek

  • Lara Divjak

  • Alojzija Brčić

  • Klara Bardač

  • Dora Višnjić

  • Radovan Vrhovac

  • Vilma Dembitz

  • Drago Batinić

  • Hrvoje Lalić

  • July 10, 2026

  • 0 min

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  • 1

    A 76-year-old man was diagnosed with simultaneous B-cell acute lymphoblastic leukemia (B-ALL) and plasma cell neoplasm (PCN) after presenting with cytopenias.

  • 2

    Initial bone marrow analysis revealed immature lymphoblasts consistent with B-ALL and a distinct population of aberrant plasma cells.

  • 3

    Treatment for B-ALL initially induced remission of both B-ALL and PCN components, but subsequent disease evolution led to relapse characterized by plasmablastic expansion.

  • 4

    Genomic analysis indicated the presence of two clonally related but distinct malignancies, suggesting early clonal divergence from a common precursor.

  • 5

    This case emphasizes the complexity of clonal evolution in B-cell malignancies and the importance of integrated genomic and immunophenotypic analysis.

Original Source(s)

Concurrent B-cell acute lymphoblastic leukemia and plasma cell neoplasm with plasmablastic features supporting divergent evolution from a shared precursor: a case report

  • by Antonija Babić, Ivana Franić Šimić, Josip Knežević, Koraljka Gjadrov Kuveždić, Ivana Ilić, Ida Ivek, Lara Divjak, Alojzija Brčić, Klara Bardač, Dora Višnjić, Radovan Vrhovac, Vilma Dembitz, Drago Batinić, Hrvoje Lalić

  • July 10, 2026

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