Assessing the Role of 3D Contrast-Enhanced CT Radiomics in Anticipating Neoadjuvant Chemotherapy Outcomes for Esophagogastric Junction Adenocarcinoma: Findings from a Dual-Center Investigation - Takeaways - MDSpire

Assessing the Role of 3D Contrast-Enhanced CT Radiomics in Anticipating Neoadjuvant Chemotherapy Outcomes for Esophagogastric Junction Adenocarcinoma: Findings from a Dual-Center Investigation

  • By

  • Chenglong Luo

  • Jing Li

  • Wanling Mu

  • Mengchen Yuan

  • Pengchao Zhan

  • Yiyang Liu

  • Yue Zhou

  • Liming Li

  • Changmao Ding

  • Xuejun Chen

  • Jianbo Gao

  • January 23, 2026

  • 0 min

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  • 1

    Adenocarcinoma of the esophagogastric junction has a high morbidity and mortality rate, with a 5-year survival rate below 30% in Western countries.

  • 2

    Neoadjuvant chemotherapy combined with surgical resection is the standard treatment for locally advanced esophagogastric junction cancer.

  • 3

    Tumor heterogeneity limits the effectiveness of neoadjuvant chemotherapy, leading to poor responses and increased toxicity in some patients.

  • 4

    This study aims to utilize 3D contrast-enhanced CT radiomics to predict the response of locally advanced AEG to neoadjuvant chemotherapy.

  • 5

    A total of 239 patients with locally advanced AEG were analyzed to evaluate clinical and pathological characteristics and NAC response.

Original Source(s)

Assessing the Role of 3D Contrast-Enhanced CT Radiomics in Anticipating Neoadjuvant Chemotherapy Outcomes for Esophagogastric Junction Adenocarcinoma: Findings from a Dual-Center Investigation

  • by Chenglong Luo, Jing Li, Wanling Mu, Mengchen Yuan, Pengchao Zhan, Yiyang Liu, Yue Zhou, Liming Li, Changmao Ding, Xuejun Chen, Jianbo Gao

  • January 23, 2026

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