Combined impact of glucose variability and mineral disorders on mortality and severe cardiorenal events in critically ill CKD patients: a multicenter cohort study

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Elevated glucose variability independently predicted 28- and 90-day mortality in critically ill elderly patients with chronic kidney disease.
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Concurrent hypocalcemia and hyperphosphatemia indicated the poorest prognosis among critically ill patients with chronic kidney disease.
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High glucose variability produced synergistic harmful effects in patients with concurrent calcium-phosphate metabolic disorders.
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The study utilized three cohorts to validate the prognostic roles of glycemic variability and mineral imbalances in mortality outcomes.
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Targeted management of glycemic variability and calcium-phosphate homeostasis may improve survival in elderly critically ill CKD patients.

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