Targeting mitochondria as a potential therapeutic strategy against radioresistance in cancer - Takeaways - MDSpire

Targeting mitochondria as a potential therapeutic strategy against radioresistance in cancer

  • By

  • Nazia Nazam

  • Shaikh Sadiya

  • Saba Khan

  • Aroonima Misra

  • Niti Sureka

  • Kirti Panwar

  • Neelam Sahani

  • Sufian Zaheer

  • June 5, 2026

  • 0 min

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  • 1

    Radioresistance in cancer therapy leads to tumor persistence and poor clinical outcomes due to intrinsic and extrinsic cellular adaptations.

  • 2

    Mitochondria play a crucial role in radioresistance by regulating bioenergetics, redox homeostasis, and apoptotic signaling.

  • 3

    Radioresistant tumor cells exhibit metabolic reprogramming, enhancing oxidative phosphorylation and antioxidant defenses under radiation stress.

  • 4

    Mitochondrial dynamics, including fusion and fission, support tumor survival by promoting mitophagy and metabolic adaptation.

  • 5

    Emerging therapeutic strategies targeting mitochondrial function aim to improve radiosensitivity and combat radioresistance in malignancies.

Original Source(s)

Targeting mitochondria as a potential therapeutic strategy against radioresistance in cancer

  • by Nazia Nazam, Shaikh Sadiya, Saba Khan, Aroonima Misra, Niti Sureka, Kirti Panwar, Neelam Sahani, Sufian Zaheer

  • June 5, 2026

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