Multi-omics analysis of long COVID (post-COVID-19 condition) reveals persistent mitochondrial dysfunction, suppressed oxidative phosphorylation, and immune dysregulation

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Post-COVID Syndrome (PCS) is characterized by persistent mitochondrial dysfunction and immune dysregulation following SARS-CoV-2 infection.
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Integrated multi-omics analysis revealed sustained suppression of mitochondrial oxidative phosphorylation (OXPHOS) across various tissues in PCS.
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Skeletal muscle showed the most significant mitochondrial repression, correlating with fatigue symptoms in both hamsters and PCS patients.
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Brain regions exhibited diverse metabolic recovery patterns, with persistent mitochondrial repression noted in cortical areas of PCS models.
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Longitudinal serum proteomics indicated ongoing mitochondrial stress and immune activation in PCS patients up to six months post-infection.

Frontiers In Immunology

by Alexia Tasoula, Shehbeel Arif, Ethan Waisberg, Lucas Bauer, Elizabeth Aslinger, Joseph W. Guarnieri
May 21, 2026

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