Commentary: Identifying key predictors of post-stroke depression and cognitive impairment in acute stroke survivors - Takeaways - MDSpire
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Insights on Key Factors Influencing Post-Stroke Depression and Cognitive Decline in Survivors of Acute Stroke

  • By

  • Polona Rus Prelog

  • Matija Zupan

  • Senta Frol

  • September 14, 2026

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  • 1

    The study by Yan et al. followed 78 acute ischemic stroke survivors to evaluate post-stroke depression and cognitive impairment over 6 months.

  • 2

    Right-hemisphere lesions, higher baseline PHQ-9 scores, and lower baseline MMSE scores independently predicted post-stroke neuropsychological burden.

  • 3

    The commentary emphasizes the need for separate models for post-stroke depression and cognitive impairment to better understand their determinants and prognosis.

  • 4

    PHQ-9 scores of ≥5 were used for screening post-stroke depression, but the low cutoff may misclassify transient symptoms as clinically significant.

  • 5

    MoCA is suggested as a more sensitive tool than MMSE for detecting cognitive deficits in post-stroke patients, particularly after right-hemisphere lesions.

Original Source(s)

Commentary: Identifying key predictors of post-stroke depression and cognitive impairment in acute stroke survivors

  • by Polona Rus Prelog, Matija Zupan, Senta Frol

  • September 14, 2026

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