Imaging patterns of hemorrhagic transformation after tenecteplase versus alteplase in real-world practice - Takeaways - MDSpire

Comparative Analysis of Hemorrhagic Transformation Imaging Following Tenecteplase and Alteplase in Clinical Practice

  • By

  • Shijie Guo

  • Dong Zhang

  • Ying Zong

  • Dongrui Huang

  • Lingyun Liu

  • Yunhua Yue

  • July 17, 2026

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  • 1

    A retrospective cohort study compared hemorrhagic transformation severity between tenecteplase and alteplase in acute ischemic stroke patients.

  • 2

    The study included 95 patients, with 41 receiving alteplase and 54 receiving tenecteplase, showing comparable baseline characteristics.

  • 3

    No significant difference in symptomatic intracranial hemorrhage (sICH) incidence was observed between the two treatment groups.

  • 4

    Higher baseline NIHSS scores and longer onset-to-needle times were independently associated with intracranial hemorrhage.

  • 5

    The Heidelberg Bleeding Classification did not reveal a significant shift in hemorrhagic severity between tenecteplase and alteplase.

Original Source(s)

Imaging patterns of hemorrhagic transformation after tenecteplase versus alteplase in real-world practice

  • by Shijie Guo, Dong Zhang, Ying Zong, Dongrui Huang, Lingyun Liu, Yunhua Yue

  • July 17, 2026

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