Anti-GPIIIa antibody and CD4 count identify an autoimmune-enriched phenotype of HIV-associated thrombocytopenia: development and internal validation of a clinical nomogram - Takeaways - MDSpire

Anti-GPIIIa antibody and CD4 count identify an autoimmune-enriched phenotype of HIV-associated thrombocytopenia: development and internal validation of a clinical nomogram

  • By

  • Xia Liu

  • Lemin Wen

  • Zhoulin Zhong

  • Hangbiao Qiang

  • Lida Mo

  • Wenyi Dong

  • Wen Huang

  • Shuyu Nong

  • Zheng Huang

  • Zhiman Xie

  • Mei Yu

  • July 7, 2026

  • 0 min

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  • 1

    Thrombocytopenia affects 11-16.3% of HIV-treated patients, posing risks of hemorrhage and complicating treatment.

  • 2

    A case-control study of 196 HIV-infected individuals identified anti-GPIIIa antibody positivity as a key predictor of thrombocytopenia.

  • 3

    The final prediction model achieved an AUC of 0.862, indicating strong performance in risk stratification for thrombocytopenia.

  • 4

    Dose-response analysis revealed distinct risk trajectories for anti-GPIIIa-positive and negative patients based on CD4+ counts.

  • 5

    The study emphasizes the need for integrated tools to assess thrombocytopenia risk and identify patients for further immunological evaluation.

Original Source(s)

Anti-GPIIIa antibody and CD4 count identify an autoimmune-enriched phenotype of HIV-associated thrombocytopenia: development and internal validation of a clinical nomogram

  • by Xia Liu, Lemin Wen, Zhoulin Zhong, Hangbiao Qiang, Lida Mo, Wenyi Dong, Wen Huang, Shuyu Nong, Zheng Huang, Zhiman Xie, Mei Yu

  • July 7, 2026

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