Distinct IgM and IgG autoantibody profiles characterize incomplete and classified systemic autoimmune diseases - Takeaways - MDSpire

Distinct IgM and IgG autoantibody profiles characterize incomplete and classified systemic autoimmune diseases

  • By

  • Rebecca A. Wood

  • Neha Kodali

  • Nancy Redinger

  • A. Darise Farris

  • Christopher J. Lessard

  • R. Hal Scofield

  • June 17, 2026

  • 0 min

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  • 1

    Incomplete lupus erythematosus (ILE) and non-Sjögren’s disease sicca (nSjD-sicca) are poorly defined autoimmune conditions with distinct immunologic features.

  • 2

    Expanded autoantibody profiling revealed increased IgM autoreactivity in ILE compared to SLE, indicating unique immune signatures for incomplete autoimmune diseases.

  • 3

    SLE demonstrated enriched IgG responses to canonical nuclear antigens, contrasting with ILE's IgM-dominant profiles targeting various antigens.

  • 4

    Ro52 IgG autoantibodies were significantly increased in Sjögren’s disease compared to nSjD-sicca, highlighting differences within the sicca spectrum.

  • 5

    The study emphasizes the potential of isotype-specific autoantibody profiling for better classification of incomplete and established autoimmune disorders.

Original Source(s)

Distinct IgM and IgG autoantibody profiles characterize incomplete and classified systemic autoimmune diseases

  • by Rebecca A. Wood, Neha Kodali, Nancy Redinger, A. Darise Farris, Christopher J. Lessard, R. Hal Scofield

  • June 17, 2026

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