Impact of COVID-19 Restrictions on Estimating Causal Effects: Fluoroquinolones and Tendon Rupture - Takeaways - MDSpire
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How COVID-19 Restrictions Affect Causal Effect Estimates: Fluoroquinolone Use and Tendon Rupture

  • By

  • Angel Y. S. Wong

  • Jeremy P. Brown

  • John Tazare

  • Marleen Bokern

  • Elizabeth Williamson

  • Jonathan Bartlett

  • Charlotte Warren-Gash

  • Ian Douglas

  • October 15, 2026

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  • 1

    The study examined whether COVID-19-related changes in health care and EHR recording affected estimates of fluoroquinolone-associated tendon rupture.

  • 2

    Researchers replicated a cohort study using UK CPRD Aurum data linked to hospital admission and death records.

  • 3

    Adults receiving a first systemic fluoroquinolone prescription were compared with adults receiving a first systemic cephalosporin prescription.

  • 4

    The outcome was the first recorded tendon rupture diagnosis during follow-up, ascertained from primary care and hospital records.

  • 5

    Four analyses varied whether exposure and outcome ascertainment used pre-pandemic, pandemic, and post-pandemic data.

Original Source(s)

Impact of COVID-19 Restrictions on Estimating Causal Effects: Fluoroquinolones and Tendon Rupture

  • by Angel Y. S. Wong, Jeremy P. Brown, John Tazare, Marleen Bokern, Elizabeth Williamson, Jonathan Bartlett, Charlotte Warren-Gash, Ian Douglas

  • October 15, 2026

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