Laparoscopic sleeve gastrectomy in adults with Prader-Willi syndrome and super-morbid obesity: a case report and literature review - Takeaways - MDSpire

Laparoscopic sleeve gastrectomy in adults with Prader-Willi syndrome and super-morbid obesity: a case report and literature review

  • By

  • Ji Li

  • Linhua Hao

  • Yuan-Hui Jiang

  • Lei Chen

  • June 15, 2026

  • 0 min

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  • 1

    Laparoscopic sleeve gastrectomy (LSG) was assessed for safety and effectiveness in adults with Prader-Willi syndrome (PWS) and super-morbid obesity.

  • 2

    A 24-year-old male with PWS and a BMI of 64.44 kg/m² underwent LSG, showing uneventful short-term recovery but uncertain long-term outcomes.

  • 3

    Literature review indicated modest weight loss from LSG in PWS patients, but significant postoperative management challenges persist.

  • 4

    LSG should not be a first-line treatment for PWS; careful patient selection and comprehensive multidisciplinary evaluation are essential.

  • 5

    Optimized perioperative management and emerging therapies may improve surgical eligibility for patients with PWS and super-morbid obesity.

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