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A Multilevel Molecular Monitoring System Connecting Swift Dengue Identification to Genomic Epidemiology in Senegal

  • By

  • Amy Gaye

  • Varun Vaidya

  • Mariama Toure

  • Ibrahima Mbaye Ndiaye

  • Sebastian Gallon

  • Mamadou Samb Yade

  • Bassirou Ngom

  • Djiby Sow

  • Ndeye Coumba Diop

  • Ousmane Kebe

  • Yaye Die Ndiaye

  • Mamadou Alpha Diallo

  • Aita Sene

  • Abdoulaye Tine

  • Awa Bineta Deme

  • Younousse Diedhiou

  • Abdoulaye Kane Dia

  • Aida S. Badiane

  • Mouhamad Sy

  • Daouda Ndiaye

  • August 25, 2026

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  • 1

    DENV, ZIKV, and CHIKV can co-circulate and produce overlapping clinical syndromes that complicate diagnosis and surveillance.

  • 2

    The study established a tiered surveillance workflow combining individual or pooled multiplex RT-qPCR, RT-RPA dengue serotyping, and genomic sequencing.

  • 3

    Multiplex RT-qPCR provided evidence of concurrent DENV, ZIKV, and CHIKV circulation among the sampled population in Senegal.

  • 4

    DENV positivity among pooled RT-qPCR tests ranged from 8.3% to 31.6% across sites, indicating geographic variation in pool-level detection.

  • 5

    The findings support linking molecular screening and rapid dengue serotyping with targeted genomic sequencing in resource-limited surveillance settings.

Original Source(s)

A tiered molecular surveillance framework linking rapid dengue detection to genomic epidemiology in Senegal

  • by Amy Gaye, Varun Vaidya, Mariama Toure, Ibrahima Mbaye Ndiaye, Sebastian Gallon, Mamadou Samb Yade, Bassirou Ngom, Djiby Sow, Ndeye Coumba Diop, Ousmane Kebe, Yaye Die Ndiaye, Mamadou Alpha Diallo, Aita Sene, Abdoulaye Tine, Awa Bineta Deme, Younousse Diedhiou, Abdoulaye Kane Dia, Aida S. Badiane, Mouhamad Sy, Daouda Ndiaye

  • August 25, 2026

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