Factors associated with relapse/progression in pediatric trunk and extremity rhabdomyosarcoma

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Rhabdomyosarcoma of the trunk and extremities has high rates of metastasis and relapse, leading to unfavorable outcomes in pediatric patients.
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The study analyzed clinical data from 15 children treated for trunk and extremity RMS at Shanghai Children’s Hospital from 2011 to 2024.
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The 5-year event-free survival rate was 60%, while the overall survival rate was 66.7%, with a 40% relapse/progression rate observed.
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Higher relapse/progression rates were linked to metastasis at diagnosis, high-risk stratification, and macroscopic residual disease after surgery.
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Regional lymph node involvement showed a trend toward increased relapse/progression rates, although the difference was not statistically significant.

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