MASLD in the cardiovascular–kidney–metabolic health framework: what does it add to the table? - Takeaways - MDSpire

MASLD in the cardiovascular–kidney–metabolic health framework: what does it add to the table?

  • By

  • Kyoung Hwa Ha

  • Dae Jung Kim

  • Hokyou Lee

  • August 27, 2025

  • 0 min

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  • 1

    The American Heart Association's CKM health framework integrates cardiovascular, kidney, and metabolic disease prevention and management.

  • 2

    Metabolic dysfunction–associated steatotic liver disease (MASLD) is a new term for non-alcoholic fatty liver disease, emphasizing metabolic dysfunction.

  • 3

    Higher fatty liver index (FLI) scores correlate with increased cardiovascular disease risk across all CKM stages, particularly in early stages.

  • 4

    Integrating MASLD metrics into CKM staging could improve early risk stratification and inform tailored prevention strategies.

  • 5

    Questions remain about the clinical utility of FLI and whether MASLD adds value to existing CVD risk stratification methods.

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