A Case of Persistently Positive Mpox PCR for 1 Year in a Patient With Advanced HIV - Takeaways - MDSpire

A Case of Persistently Positive Mpox PCR for 1 Year in a Patient With Advanced HIV

  • By

  • Haitham Alaithan

  • Neha Venkatesh

  • Prathit A Kulkarni

  • Richard J Hamill

  • Maria C Rodriguez-Barradas

  • April 16, 2025

  • 0 min

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  • 1

    Mpox is a self-limited disease caused by the monkeypox virus, typically resolving within 4 weeks in immunocompetent individuals.

  • 2

    This report details a case of prolonged Mpox PCR positivity lasting over one year in a patient with advanced HIV infection.

  • 3

    The patient, a 41-year-old man with AIDS, experienced persistent skin lesions despite treatment with tecovirimat.

  • 4

    Multiple PCR tests confirmed ongoing Mpox infection, with positive results over a span of 3 months during hospitalization.

  • 5

    The patient ultimately achieved resolution of skin lesions and negative PCR results after extensive antiviral therapy.

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