Systemic immune remodeling following curative (R0) resection of colorectal liver metastases - Takeaways - MDSpire

Systemic immune remodeling following curative (R0) resection of colorectal liver metastases

  • By

  • Shuo Ren

  • Migmar Tsamchoe

  • Stephanie K. Petrillo

  • Oran Zlotnik

  • Jessica Bloom

  • Anastasia Tsatoumas

  • Vered Domankevich

  • Anthoula Lazaris

  • Peter Metrakos

  • July 9, 2026

  • 0 min

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  • 1

    Colorectal cancer liver metastases (CRLM) contribute to systemic immunosuppression and poor prognosis, necessitating further study of immune landscape changes post-resection.

  • 2

    Surgical resection of CRLM leads to significant remodeling of T cell composition, particularly an increase in CD4+ T cells among circulating CD3+ T cells.

  • 3

    Postoperative analysis showed a decrease in TIM3+ CD4+ T cells, while PD-1+ CD4+ T cells exhibited modest downward trends, indicating changes in immune exhaustion markers.

  • 4

    Patients with recurrence had a higher proportion of S100A9+ monocytic myeloid-derived suppressor cells (M-MDSCs) post-surgery, suggesting a link to poor outcomes.

  • 5

    KRAS-mutated tumors may be associated with distinct postoperative immune profiles, highlighting the need for further investigation into immune responses after liver resection.

Original Source(s)

Systemic immune remodeling following curative (R0) resection of colorectal liver metastases

  • by Shuo Ren, Migmar Tsamchoe, Stephanie K. Petrillo, Oran Zlotnik, Jessica Bloom, Anastasia Tsatoumas, Vered Domankevich, Anthoula Lazaris, Peter Metrakos

  • July 9, 2026

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