Association between the fibrosis-4 index and carotid atherosclerosis in Chinese patients with type 2 diabetes mellitus: a cross-sectional study - Takeaways - MDSpire

Association between the fibrosis-4 index and carotid atherosclerosis in Chinese patients with type 2 diabetes mellitus: a cross-sectional study

  • By

  • Bo Huang

  • Yi-Rui Liang

  • Shi-Wei Li

  • Ya-Ning Li

  • Jing-Qiu Cui

  • July 13, 2026

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  • 1

    The study included 1,045 patients with type 2 diabetes mellitus (T2DM) to investigate the association between the FIB-4 index and carotid atherosclerosis (CAS).

  • 2

    Higher FIB-4 levels were linked to increased odds of CAS, with odds ratios for the second, third, and fourth quartiles being 1.16, 1.75, and 2.04, respectively.

  • 3

    Receiver operating characteristic analysis showed limited discriminatory performance of FIB-4 for CAS, with an area under the curve of 0.579.

  • 4

    Weaker associations were found for lower extremity arterial disease (LEAD) and diabetic peripheral neuropathy (DPN), with AUCs of 0.587 and 0.532, respectively.

  • 5

    The study concluded that elevated FIB-4 is significantly associated with higher risks of CAS and LEAD in T2DM patients, particularly for CAS.

Original Source(s)

Association between the fibrosis-4 index and carotid atherosclerosis in Chinese patients with type 2 diabetes mellitus: a cross-sectional study

  • by Bo Huang, Yi-Rui Liang, Shi-Wei Li, Ya-Ning Li, Jing-Qiu Cui

  • July 13, 2026

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