Case Report: Spectral CT characterization of giant esophageal schwannoma with reactive lymphoid hyperplasia mimicking lymphoproliferative disease - Takeaways - MDSpire

Case Report: Spectral CT characterization of giant esophageal schwannoma with reactive lymphoid hyperplasia mimicking lymphoproliferative disease

  • By

  • Zuyi Fan

  • Anqi Zhang

  • Yumeng Xi

  • Meng Wang

  • Zhenzhen Fan

  • Zhihui Dong

  • July 3, 2026

  • 0 min

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  • 1

    Esophageal schwannoma is a rare mesenchymal tumor often misdiagnosed due to overlapping features with other esophageal masses.

  • 2

    A 48-year-old woman presented with mild dysphagia and an incidentally found right mediastinal mass measuring 83 × 63 × 100 mm.

  • 3

    Spectral CT provided enhanced imaging, revealing heterogeneous enhancement and significant differences in attenuation values compared to conventional CT.

  • 4

    Histopathology confirmed a spindle-cell tumor with a prominent lymphoid cuff, and immunohistochemical profiling supported the diagnosis of schwannoma.

  • 5

    The patient underwent partial esophagectomy and targeted adjuvant radiotherapy due to the tumor's size and proximity to major vascular structures.

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