Excessive Rescue Inhaler Use Associated With Higher Cardiovascular Disease Risk

1

In a nationwide Belgian cohort, approximately 17% of patients with asthma and 30% of patients with COPD used at least 3 short-acting bronchodilator canisters during baseline.
2

Compared with no use, SAMA and SABA+SAMA exposure was associated with higher risks of heart failure, arrhythmia, and all-cause mortality in patients with asthma and COPD.
3

Among patients with asthma, use of 1 to 2 or at least 3 SABA+SAMA canisters annually was associated with higher risks of myocardial infarction and ischemic stroke.
4

Among patients with COPD, use of at least 3 SABA+SAMA canisters annually was associated with a 1.4-fold higher risk of myocardial infarction.
5

Use of at least 3 SABA canisters annually was associated with 1.1-fold higher risks of heart failure and mortality in patients with asthma and COPD, whereas use of 1 to 2 canisters was not.

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