Established and emerging prognostic factors in mycosis fungoides and Sézary syndrome - Takeaways - MDSpire

Established and emerging prognostic factors in mycosis fungoides and Sézary syndrome

  • By

  • Viviane Liao

  • Robert N. Stuver

  • Shamir Geller

  • July 1, 2026

  • 0 min

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  • 1

    Mycosis fungoides and Sézary syndrome are the most common subtypes of cutaneous T-cell lymphoma, characterized by variable prognosis.

  • 2

    Accurate prognostication in MF and SS is essential for risk-adapted management and involves both traditional and advanced prognostic factors.

  • 3

    The TNMB classification system for MF/SS has undergone revisions, emphasizing blood staging and clonality assessment.

  • 4

    Stage remains a key prognostic factor, with higher TNMB classification associated with reduced survival.

  • 5

    Blood stage is a newly added prognostic factor, with recent changes in classification potentially affecting patient prognosis.

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