T cells turn in Alzheimer’s disease

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The study highlights the role of T lymphocytes in Alzheimer's disease (AD) and their potential link to neurodegeneration.
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Rickenbach et al. characterized T cell changes in early AD using advanced techniques like mass cytometry and single-cell RNA sequencing.
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Increased CD8+ T effector memory cells re-expressing CD45RA were found in blood and CSF of amyloid-positive individuals.
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The research indicates a pro-inflammatory profile in CD8+ TEMRA cells from individuals with mild cognitive impairment.
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Changes in CD4+ T cell populations were also observed, suggesting a complex interplay between T cell subsets in AD pathology.