MRI features and radiomics of the pineal gland in girls do not show significant changes at onset of puberty - Takeaways - MDSpire

MRI features and radiomics of the pineal gland in girls do not show significant changes at onset of puberty

  • By

  • Anna-Mariia Shulhai

  • Michele Maddalo

  • Maddalena Petraroli

  • Francesca Ormitti

  • Benedetta Piccolo

  • Emanuela Claudia Turco

  • Nicola Sverzellati

  • Caterina Ghetti

  • Susanna Esposito

  • Maria Elisabeth Street

  • May 29, 2026

  • 0 min

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  • 1

    The study involved 45 girls with central precocious puberty (CPP) and 47 age-matched controls to evaluate pineal gland characteristics.

  • 2

    Radiomic analysis of the pineal gland showed no significant changes associated with the onset of puberty in the studied population.

  • 3

    Two radiomic features were identified as predictive of CPP, but inter-reader reliability was poor and validation performance was unpromising.

  • 4

    The reference model based on pineal cyst features also demonstrated poor performance, with a ROC-AUC of 0.52 for both readers.

  • 5

    No significant correlations were found between pineal cyst features and basal or peak gonadotropin levels in the study.

Original Source(s)

MRI features and radiomics of the pineal gland in girls do not show significant changes at onset of puberty

  • by Anna-Mariia Shulhai, Michele Maddalo, Maddalena Petraroli, Francesca Ormitti, Benedetta Piccolo, Emanuela Claudia Turco, Nicola Sverzellati, Caterina Ghetti, Susanna Esposito, Maria Elisabeth Street

  • May 29, 2026

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