Clinical characteristics and cytokine profiles for early prediction of severe Mycoplasma pneumoniae pneumonia in children: a prospective cohort study - Takeaways - MDSpire
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Early Identification of Severe Mycoplasma pneumoniae Pneumonia in Pediatric Patients: A Prospective Study on Clinical Features and Cytokine Profiles

  • By

  • Jiayi Xue

  • Tao Ai

  • Yinghong Fan

  • Cheng Xie

  • Wanmin Xia

  • Li Wang

  • July 10, 2026

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  • 1

    The study enrolled 445 children with Mycoplasma pneumoniae pneumonia, categorizing them into mild and severe groups based on disease severity.

  • 2

    Independent risk factors for severe Mycoplasma pneumoniae pneumonia included wheezing, shortness of breath, fever, D-dimer, CRP, and age.

  • 3

    The predictive nomogram developed from the study showed an area under the curve (AUC) of 0.818, indicating good predictive ability for severe cases.

  • 4

    Cytokine levels of HMGB-1, TFEB, MCP-1, MCP-2, MCP-3, MCP-4, and TNF-α were significantly higher in severe cases compared to mild cases.

  • 5

    The study highlights the importance of early identification of severe Mycoplasma pneumoniae pneumonia through clinical features and cytokine profiles.

Original Source(s)

Clinical characteristics and cytokine profiles for early prediction of severe Mycoplasma pneumoniae pneumonia in children: a prospective cohort study

  • by Jiayi Xue, Tao Ai, Yinghong Fan, Cheng Xie, Wanmin Xia, Li Wang

  • July 10, 2026

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