Clinical characteristics and cytokine profiles for early prediction of severe Mycoplasma pneumoniae pneumonia in children: a prospective cohort study

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The study enrolled 445 children with Mycoplasma pneumoniae pneumonia, categorizing them into mild and severe groups based on disease severity.
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Independent risk factors for severe Mycoplasma pneumoniae pneumonia included wheezing, shortness of breath, fever, D-dimer, CRP, and age.
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The predictive nomogram developed from the study showed an area under the curve (AUC) of 0.818, indicating good predictive ability for severe cases.
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Cytokine levels of HMGB-1, TFEB, MCP-1, MCP-2, MCP-3, MCP-4, and TNF-α were significantly higher in severe cases compared to mild cases.
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The study highlights the importance of early identification of severe Mycoplasma pneumoniae pneumonia through clinical features and cytokine profiles.

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