Single-cell investigations uncover interactions between TREM1-expressing myeloid cells and cancer-associated fibroblasts during colorectal cancer development - Takeaways - MDSpire

Single-cell investigations uncover interactions between TREM1-expressing myeloid cells and cancer-associated fibroblasts during colorectal cancer development

  • By

  • Shang-Yin Wu

  • Po-Chuan Chen

  • Ren-Hao Chan

  • Chung-Hsing Chen

  • Yi-Hsuan Huang

  • Yi-Jing Huang

  • Bing-Syuan Chung

  • Che-Hung Shen

  • Hsin-Yu Kuo

  • Jui-Wen Kang

  • Chung-Ta Lee

  • Hui-Ju Tsai

  • Yu-Chen Fang

  • Peng-Chan Lin

  • Yu-Min Yeh

  • Shang-Hung Chen

  • April 27, 2026

  • 0 min

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  • 1

    Colorectal cancer (CRC) is a major cause of cancer-related mortality, with immune checkpoint inhibitors often ineffective in microsatellite-stable cases.

  • 2

    Tumor-associated myeloid cells (TAMCs) adopt an immunosuppressive phenotype, contributing to resistance against immune checkpoint inhibitors in MSS CRC.

  • 3

    Cancer-associated fibroblasts (CAFs) promote tumor progression and therapy resistance by remodeling the extracellular matrix and secreting cytokines.

  • 4

    Single-cell RNA sequencing revealed TREM1-positive myeloid cells and ACTA2-positive CAFs interact through SPP1 signaling, influencing CRC development.

  • 5

    The study aims to elucidate the functional interplay between TREM1-positive myeloid cells and ACTA2-positive CAFs in shaping the tumor microenvironment.

Original Source(s)

Single-cell investigations uncover interactions between TREM1-expressing myeloid cells and cancer-associated fibroblasts during colorectal cancer development

  • by Shang-Yin Wu, Po-Chuan Chen, Ren-Hao Chan, Chung-Hsing Chen, Yi-Hsuan Huang, Yi-Jing Huang, Bing-Syuan Chung, Che-Hung Shen, Hsin-Yu Kuo, Jui-Wen Kang, Chung-Ta Lee, Hui-Ju Tsai, Yu-Chen Fang, Peng-Chan Lin, Yu-Min Yeh, Shang-Hung Chen

  • April 27, 2026

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