Bone Microarchitecture Evaluated by HR-PQCT in Chinese Adolescent and Pediatric Patients With X-Linked Hypophosphatemia - Takeaways - MDSpire

Bone Microarchitecture Evaluated by HR-PQCT in Chinese Adolescent and Pediatric Patients With X-Linked Hypophosphatemia

  • By

  • Yushuo Wu

  • Yisen Yang

  • Xiaosen Ma

  • Qianqian Pang

  • Yue Chi

  • Ruizhi Jiajue

  • Wei Liu

  • Yan Jiang

  • Ou Wang

  • Mei Li

  • Xiaoping Xing

  • Lijia Cui

  • Weibo Xia

  • November 14, 2024

  • 0 min

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  • 1

    X-linked hypophosphatemia (XLH) is the most common heritable hypophosphatemic rickets, leading to bone deformities and short stature in affected individuals.

  • 2

    This study assessed bone microarchitecture in 106 Chinese pediatric and adolescent patients with XLH using high-resolution peripheral quantitative computed tomography (HR-pQCT).

  • 3

    Patients with XLH exhibited higher trabecular area and lower bone mineral density and stiffness compared to age- and sex-matched controls.

  • 4

    Alkaline phosphatase Z score (ALP-Z) negatively correlated with cortical bone density and thickness, indicating its potential as a marker for skeletal quality.

  • 5

    An online calculator was developed to estimate HR-pQCT parameters based on clinical and biochemical data, aiding assessment in areas lacking HR-pQCT access.

Original Source(s)

Bone Microarchitecture Evaluated by HR-PQCT in Chinese Adolescent and Pediatric Patients With X-Linked Hypophosphatemia

  • by Yushuo Wu, Yisen Yang, Xiaosen Ma, Qianqian Pang, Yue Chi, Ruizhi Jiajue, Wei Liu, Yan Jiang, Ou Wang, Mei Li, Xiaoping Xing, Lijia Cui, Weibo Xia

  • November 14, 2024

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