Cell-dependent antithrombotic effect of tranexamic acid - Takeaways - MDSpire

Cell-dependent antithrombotic effect of tranexamic acid

  • By

  • Kata Balog Virág

  • Petra Csikós

  • Alexandra Raska

  • Barbara Baráth

  • Kristóf Molnár

  • Natalia Nikolova

  • Kiril Tenekedjiev

  • Krasimir Kolev

  • Nikolett Wohner

  • May 26, 2026

  • 0 min

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  • 1

    Tranexamic acid (TXA) inhibits fibrinolysis by blocking lysine-binding sites on plasminogen and plasmin.

  • 2

    TXA reduced venous thrombus formation by 90% in a murine model without affecting thrombus mass or primary hemostasis.

  • 3

    TXA decreased thrombin generation in whole blood but not in platelet-rich plasma, indicating a cellular requirement.

  • 4

    TXA suppressed the rise in MCP-1 induced by stenosis, suggesting modulation of inflammatory responses.

  • 5

    TXA's effects on thrombus formation are context- and timing-dependent, with varying outcomes based on administration route and patient factors.

Original Source(s)

Cell-dependent antithrombotic effect of tranexamic acid

  • by Kata Balog Virág, Petra Csikós, Alexandra Raska, Barbara Baráth, Kristóf Molnár, Natalia Nikolova, Kiril Tenekedjiev, Krasimir Kolev, Nikolett Wohner

  • May 26, 2026

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