Pathogen effects on the brain: the case of SARS-CoV-2 spike protein and neuro COVID

1

Approximately 50% of patients infected with SARS-CoV-2 develop Long-COVID, characterized by persistent fatigue and neuropsychiatric symptoms.
2

Long-COVID symptoms may persist for months, with neurological disorders including headache, anosmia, and cognitive impairment reported.
3

The Spike protein of SARS-CoV-2 may contribute to neuroinflammation by activating mast cells and microglia, leading to neurotoxic effects.
4

Epidemiological data indicate varying prevalence of Long-COVID across SARS-CoV-2 variants, with the ancestral strain showing the highest rates.
5

The mechanisms underlying Long-COVID remain unclear, involving complex immune responses and potential disruptions in the blood-brain barrier.

1