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1
Approximately 50% of patients infected with SARS-CoV-2 develop Long-COVID, characterized by persistent fatigue and neuropsychiatric symptoms.
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2
Long-COVID symptoms may persist for months, with neurological disorders including headache, anosmia, and cognitive impairment reported.
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3
The Spike protein of SARS-CoV-2 may contribute to neuroinflammation by activating mast cells and microglia, leading to neurotoxic effects.
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4
Epidemiological data indicate varying prevalence of Long-COVID across SARS-CoV-2 variants, with the ancestral strain showing the highest rates.
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5
The mechanisms underlying Long-COVID remain unclear, involving complex immune responses and potential disruptions in the blood-brain barrier.
