Potential targets for boron transport in boron neutron capture therapy - Takeaways - MDSpire

Potential targets for boron transport in boron neutron capture therapy

  • By

  • Yucai Wei

  • Weijing Zhu

  • Qian Chen

  • Huda Alnufaei

  • Yumin Li

  • Kate Ricketts

  • May 28, 2026

  • 0 min

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  • 1

    Boron Neutron Capture Therapy (BNCT) combines boron drug administration with neutron irradiation to selectively kill cancer cells.

  • 2

    Effective BNCT requires tumor boron concentrations of ≥ 20 μg/g and favorable tumor-to-normal tissue concentration ratios.

  • 3

    Two approved boron carriers for BNCT are sodium mercaptoundecahydrododecaborate-10B and boronophenylalanine-10B.

  • 4

    L-type amino acid transporter 1 (LAT1) is crucial for the transport of boronophenylalanine in tumor cells.

  • 5

    Elevated LAT1 expression in tumors correlates with increased boron uptake and poor clinical outcomes.

Original Source(s)

Potential targets for boron transport in boron neutron capture therapy

  • by Yucai Wei, Weijing Zhu, Qian Chen, Huda Alnufaei, Yumin Li, Kate Ricketts

  • May 28, 2026

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